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AsnC, a global transcriptional regulator that controls the response to poor nutritional conditions, which are sensed by binding of this regulator to leucine and methionine

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In some cases, an ultraviolet light called a Wood's lamp is used to highlight areas of depigmentation, which appear chalky and bright under the lamp

Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size